Position Overview
DescriptionThe laboratory studies human brain development and neuropsychiatric disease using stem cell–derived organoids and primary fetal tissue. Current projects focus on:
Defining how radial glia give rise to hippocampal and neocortical lineages, and identifying signaling pathways (e.g., Wnt and beyond) that govern hippocampal subfield specification Building and characterizing human hippocampal organoid systems, including efforts to engineer missing subfields (e.g., CA1/CA3/DG) Identifying conserved molecular and cellular programs across genetic and pharmacologic models of schizophrenia using large-scale single-cell and multiomic datasets Modeling neurodevelopmental contributions to schizophrenia through perturbation systems, including chronic and acute NMDA receptor inhibition (e.g., ketamine exposure) Developing scalable perturbation platforms (e.g., inducible CRISPRa/i systems) to systematically interrogate candid...