The Singapore Institute of Food and Biotechnology Innovation (SIFBI) at A*STAR studies the digestibility and microbiome fermentation of food materials and ingredients to better understand their nutritional profiles. A key platform for this work is the Simulator of the Human Intestinal Microbial Ecosystem (SHIME), an in vitro digestion system. The SHIME system enables dynamic control of pH, acids/bases, bile salts and enzymes to simulate stomach, intestinal and colonic digestion. Regional sampling allows us to assess digestion along different segments of the intestinal tract and to monitor microbiome responses to foods and pre/probiotics. Such insights are difficult to obtain in human studies due to invasive sampling requirements, and animal models often do not accurately mimic human digestion. This is the first fully automated dynamic digestion system available to the public sector in Singapore.

We are seeking a Laboratory Officer or Research Officer to be trained in the operation a...