Full time.

Overall purpose:

To work within the group of Dr Manu Hegde at the MRC Laboratory of Molecular Biology (LMB), within a programme aimed at understanding protein biosynthesis and quality control.

For cells to function properly, newly synthesised proteins must be accurately delivered to their correct cellular destinations and, in many cases, assembled with other proteins into larger complexes. Our group investigates the molecular mechanisms underlying these processes, together with the pathways that detect and resolve errors in protein maturation. In particular, we are interested in how cells recognise and clear aberrant proteins, including unassembled subunits of multi-protein complexes. Defects in these and related quality control pathways are associated with numerous human diseases, including neurodegeneration and cancer, highlighting their essential role in maintaining cellular homeostasis.

Main duties/key responsibilities: