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Principal Scientist - RGM Chemistry

Regeneron Pharmaceuticals
Location 📍 Hawthorne, United States
Posted 📅 June 14, 2026
Work Type ⏰ Full-time

Position Overview

We are looking for a visionary Principal Scientist – RGM Chemistry to lead the discovery, development, and optimization of antibody-oligonucleotide conjugation technologies that power next-generation targeted therapeutics. Sitting at the intersection of bioconjugation chemistry, RNA science, and process innovation, you will set scientific strategy, guide a multidisciplinary team, and translate ground breaking concepts into scalable solutions that advance our therapeutic pipeline. Your deep expertise, collaborative attitude, and passion for mentoring will drive breakthrough medicines from bench to preclinical validation and beyond.

**In this role, a typical day might include the following:**
- Designing and completing experiments to refine linker chemistry, payload stability, and delivery efficiency for antibody-oligo conjugates
- Analyzing conjugates with HPLC, LC-MS, and bioassays to ensure purity, identity, and functional potency
- Leading project stand-ups, mentori...

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Job Details

Employment Type
Full-time
📊
Category
other-general
🏠
Work Arrangement
On-site
📍
Location
Hawthorne, United States