Interested in exploring the role of adipose tissues in mucosal inflammation in a supportive, creative, and inclusive environment?

The Grasset lab

Our lab’s long-term objective is to uncover novel mechanisms underlying the pathology of Crohn’s disease (CD), a progressive incurable disease characterized by transmural intestinal inflammation leading to complications often requiring bowel resection surgery. The goal is to identify novel therapeutic targets by focusing on two previously disconnected hallmarks of CD: expanded mesenteric adipose tissue wrapping around the intestine – or creeping fat – and anti-microbial antibodies, both correlating with disease complications.

Studying these hallmarks will further reveal unexplored relationships between adipocytes, stromal cells, and immune cells driving B cell responses in gut homeostasis and inflammation. Understanding these relationships will impact how we per...