Make progress towards understanding and preventing chemotherapy-induced neurotoxicity.

Job description

Chemotherapy has greatly improved cancer survival, but many patients experience severe neurological side effects during or after treatment. These include peripheral neuropathy, causing numbness or pain in hands and feet, as well as cognitive problems often referred to as “chemobrain”, which can affect memory. These complications can persist long after treatment has ended, severely affecting quality of life and, in some cases, forcing dose reduction or therapy stop. Currently, there are no effective treatments to prevent these severe side effects.

In this KWF-funded project, we investigate how chemotherapy-induced DNA damage disrupts gene transcription in nerve cells and how this contributes to neurotoxicity. This project is a close collaboration between the labs of Jurgen Marteijn, Debbie van den Berg and ...