Position Summary Our laboratory investigates the HIV host–pathogen interface with the goal of identifying mechanisms that enable the immune system to control and ultimately eliminate persistent infection. We focus on defining host pathways that can be therapeutically leveraged to target the HIV reservoir. Our work integrates molecular virology, primary human cell systems, and in vivo models. We routinely work with ex vivo primary cells and patient-derived specimens and employ humanized mouse models to enable mechanistic studies and forward genetic approaches. These platforms allow us to move efficiently from mechanistic discovery toward translational strategies aimed at developing new therapeutic interventions. Trainees in the laboratory are supported in developing independent research directions and are encouraged to pursue projects that bridge fundamental virology, immunology, and translational investigation. The laboratory environment emphasizes collaboration, rigorous experimen...