The Ishizuka Lab at Yale Cancer Center is seeking an exceptional, highly motivated postdoctoral researcher to join an integrated computational–wet lab team developing new cancer immunotherapies.

We study how tumors evade the immune system through innate immune signaling, with a particular focus on double-stranded RNA sensing, viral mimicry, and innate immune checkpoints. We develop new ways to interrogate and reprogram these interactions, from patient tumors through to engineered therapeutic molecules. Our work spans perturbational single-cell profiling of human tumors (PERCEPT), AI-informed virtual screening, CRISPR-based functional genomics, mRNA therapies, and the design and directed evolution of AI-generated therapeutic binders.

The successful candidate will lead projects in related areas of the lab:

1. Translational perturbational profiling of patient tumors following treatment with novel immunotherapies using perturbational single cel...