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**Description**

The laboratory delves into the intricate mechanisms governing basal and pathological bone turnover at the Immuno-skeletal Interface. This field, known as “osteoimmunology,” explores the paradoxical role of immune cells and cytokines in driving skeletal metabolism. Our research encompasses the targeting of anergic T cells to stimulate bone formation and the utilization of costimulation inhibitors targeting CD8 T cells to enhance skeletal regeneration. Additionally, we investigate the mechanisms and functions of the microbiota underlying skeletal damage associated with HIV immunodeficiency. This includes HIV-antiretroviral therapy-induced immune reconstitution...