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The Title of the project is:
Mechanisms underlying the intergenerational effects of Mycobacterium vaccae ATCC T to promote stress resilience in mice.



According to the Old Friends hypothesis, reduced exposure, particularly during early pre- and postnatal life, to immunoregulatory microorganisms contributes to the increased prevalence of stress-associated disorders in urban concrete landscapes of high-income countries. Accordingly, our own preclinical studies demonstrate that non-pathogenic rapid-growing mycobacteria (RGMs), including M. vaccae NCTC and M. vaccae ATCC T, have immunoregulatory and stress-protective effects when administered repeatedly prior ...